Firmer skin, with a treatment chosen for your individual needs.
If your skin feels less firm, collagen biostimulators may help improve its firmness and structural support without surgery. There are several options, each with a different role.
At Clínica Provença in Barcelona, we start by understanding what you would like to improve and assessing which approach is right for you.
We provide guidance based on medical expertise.
Collagen biostimulators improve skin firmness, density and elasticity, while helping restore support where the face or body has gradually lost it. They work by stimulating your skin to produce collagen again, one of the proteins responsible for its firmness and structure. These treatments are also referred to as collagen inducers.
They do not work in the same way as fillers. Some can also add a degree of volume, but their main purpose is to improve the quality and support of your existing tissue, with an effect distributed across the treated area rather than focused on reshaping one specific point.
Treatment takes around 30 minutes in the clinic. We inject the product into the areas agreed in your treatment plan and give you straightforward aftercare advice before you leave.
Each biostimulator works differently. There is no single best option: the choice depends on what has changed in your skin or tissues and which area needs treatment.
If you want to restore firmness and elasticity to the skin on your face, neck or décolletage, we first assess what your skin needs. When skin quality is the main concern and laxity is mild, we may consider a hyaluronic acid complex (Profhilo), which works differently from a collagen biostimulator.
If your skin has lost firmness and density, we may recommend poly-L-lactic acid (Sculptra), which works gradually.
If your cheeks or facial contours have lost support, diluted calcium hydroxylapatite (Radiesse) can improve firmness and support together. Your skin thickness helps determine the dilution and injection depth. Another option is a hybrid of hyaluronic acid and calcium hydroxylapatite (HArmonyCa), which provides an initial filling effect followed by continued improvement.
The choice depends on where support is needed and how much is appropriate. If the loss of volume comes from the fat that supports the cheeks, we may also consider a hyaluronic acid complex formulated for that tissue layer.
If you would like firmer skin on your arms, abdomen, buttocks or legs, we plan treatment area by area. Poly-L-lactic acid is often the starting point, although other options may be suitable in certain areas. The decision depends on what the area has lost — skin quality or underlying support — and the size of the area being treated. Our aim is firmness, not added volume.
For targeted volume restoration in the face or body, a hyaluronic acid filler may be more appropriate. Lines caused by facial movement call for an expression-line treatment. For facial skin laxity, thread lifting can complement a biostimulator. If there is excess skin, we will discuss other options with you.
Aesthetic doctor, educator in aesthetic medicine and director of Clínica Provença.
Treatments guided by medical judgment, with personalised planning and a conservative approach.
Licensed physician No. 55671 · Barcelona Medical Association
The improvements you may see depend on the area treated:
Your skin begins producing collagen again, while we tailor the amount and placement of product to you: your own features, with improved firmness and support.
A biostimulator improves the quality of your own tissue, helping restore firmness and support. It cannot remove excess skin or lift tissue that has descended significantly. If that is your main concern, we will explain what treatment can realistically achieve and when a surgical assessment may make more sense.
Biostimulators can be combined with treatments that address different concerns, such as hyaluronic acid, polynucleotides or, for facial skin laxity, thread lifting.
We listen to your concerns and what you hope to achieve.
We assess what has changed and where: whether the main issue is the skin itself, the support beneath it or the fat that provides structure. We also consider your skin thickness, which influences the treatment choice and injection technique, as well as any previous treatments, so that the new treatment works in harmony with what is already there.
We give you a clear, medically reasoned recommendation: which treatment is appropriate, which is not, and why. Sometimes another technique is a better choice; sometimes no treatment is needed.
You leave with a treatment plan and a quotation, and can take your time deciding.
Would you like us to assess your case?
We’ll go through the available options with you.
Free initial consultation · 30 minutes
It depends on the treatment. With some options, such as hybrid injectables, you may see an initial effect straight away. With others, such as poly-L-lactic acid, there may be very little visible change at first. In both cases, results continue to develop over the following weeks and months. Before treatment, we explain what you can expect at each stage.
Age alone is not the deciding factor. What matters is the condition of your tissue today, which is what we assess first. Before starting, we explain what may be achievable in your case, although the exact response of each person’s skin cannot be predicted.
Often more than one, planned in stages. The number depends on your goals, the treatment area and the product chosen. We will discuss this during your consultation.
Results are not permanent, and their duration depends on the product, the area treated and your skin. You can find further details on each treatment page. We plan maintenance according to how your results develop.
To minimise risks, we review your medical history and adapt the technique to the product, treatment area and your skin. Common side effects are mild and temporary, including swelling, redness, tenderness or bruising. As with any injectable treatment, there are also less common risks, which we explain before proceeding. Treatment is postponed if you have an active infection in the area, or during pregnancy or breastfeeding.
They work differently, even when they share a similar goal. A hyaluronic acid filler occupies space: it adds volume exactly where it is placed, with an effect you can see from the first day. It can, for example, add projection to the cheekbones or soften a specific fold.
A biostimulator encourages your skin to respond by stimulating the tissue to improve firmness and support across a wider area, such as the cheeks or facial contours. Some also provide a degree of volume. The two are often combined, each serving a different purpose.
For facial skin laxity, Dr Gheorghiu often starts with collagen biostimulators, as they improve tissue quality and support throughout the area, which is often what has been lost.
Threads work differently: they support the tissue along their path and in a specific direction, while also providing some firmness along that path. This is why she may recommend them when targeted support is needed in addition to an overall improvement. If combining treatments would benefit you, we explain what each contributes and in what order.
No single collagen biostimulator is right for every face. We assess whether the priority is improving skin quality, restoring support or both, as well as the area being treated and any previous treatments. A faster initial effect does not make one option better: what matters is how well it suits your anatomy and the change you want to achieve.
The cost depends on the product, the amount needed, the treatment area and the number of sessions planned. We explain the full quotation after your consultation, before you decide.
Clínica Provença is located in Barcelona, at Carrer de Roger de Llúria 89, 08009 Barcelona, in a central, well-connected area.
You’ll find us a few minutes from Diagonal (L3 and L5) and Girona (L4) metro stations, as well as Passeig de Gràcia (Rodalies) and FGC Provença.
Reviewed by Dr. Manuela Gheorghiu
Last reviewed: October 2026
Dr. Manuela Gheorghiu is the Medical Director of Clínica Provença in Barcelona, where she defines the clinic’s clinical standards and treatment protocols, and practices as an aesthetic doctor.
Professor of the Master in Aesthetic Medicine and Comprehensive Rejuvenation of the Catholic University of Valencia and the European Medical College.
Graduated in Medicine and Surgery with highest honours from the Carol Davila University of Medicine and Pharmacy in Bucharest, with her medical degree officially recognised in Spain.
She completed her specialised training in Aesthetic Medicine in Spain, earning a Master’s Degree in Aesthetic Medicine from the University of Córdoba.
She maintains ongoing scientific training, with a strong focus on clinical safety and precision in both treatment indication and execution.
Member of the College of Physicians of Barcelona (COMB), with the number of collegiate 55671, and holder of the Diploma of Accreditation of Training in Aesthetic and Cosmetic Medicine (DIACAP), issued by the COMB.
Member of the Spanish Society of Aesthetic Medicine (SEME) with the number 2729.
Member of the Association of Aesthetic Doctors of Catalonia (SMEC) with the number 65.
Member of the Spanish Society of Fat Transplant Applications (SETGRA).
Professor of the Master in Aesthetic Medicine and Comprehensive Rejuvenation of the Catholic University of Valencia and the European Medical College.
Advanced training and ongoing participation in specialised national and international programmes in Aesthetic Medicine.
Her main areas of expertise include:
Inject Art Lab Course, Advanced Clinical Training in Regenerative Aesthetic Medicine, IT Pharma (2026).
Full-Face and Anatomy workshop, Croma Anatomy, Medical University of Vienna, Center for Anatomy and Cell Biology (2026).
Ultrasound in Aesthetic Medicine: Present and Future, Barcelona Medical Association (2026).
41st National Congress of Aesthetic Medicine and 7th SERECAP Congress (Spanish Society of Hair Restoration), 2026.
Practical fundamentals of aesthetic ultrasound, Dermica Laboratories (2026).
Dermamelan Expert Meeting: leading medical approach to depigmentation, Mesoestetic (2025)
Latest trends in Thread Tightening: Anatomy, advanced technique and results, Croma (2025).
Buttock approach: “New Round Raised Technique”, Dermica Laboratoires (2025).
Galderma Gain Spark Training: “Shaping Progress in Aesthetics’ Real-World Knowledge, Highlighting the latest trends and treatment innovation” (2025).
Well Aging training module: mastering the art of “less is more” and stimulating collagen production for better skin quality, Galderma (2025).
Hands on Sculptra, collagen biostimulator, Galderma (2025).
Seminar on ‘Addressing Facial Sagging in Aesthetic Medicine,’ Barcelona Medical Association (2025).
“Natural Beauty” training: enhance natural beauty with facial harmonization techniques and dynamic wrinkle treatment, Galderma Academy (2025).
Professional seminar ‘Medical-aesthetic treatment with hyaluronic acid in the mid-face and under-eye area’, Barcelona Medical Association (2025).
24th World Congress of Aesthetic Medicine (2025).
40th Congress of the Spanish Society of Aesthetic Medicine (2025).
Nuceiva neuromodulator training, anatomy and clinical results, Evolus Inc. (2024).
Hands on: Launch of Galderma’s NEW neuromodulator Relfydess (2024).
Practical Theoretical Workshop – Special: Collagen Biostimulator, Galderma (2024).
Skymedic Regenerative Day: Exosomes, advanced photobiodynamic therapy and carboxytherapy (2024).
Teoxane’s course in Aesthetic Medicine, advanced level: facial anatomy, middle third and redensification, upper third, rheology, eyebrows, lips and gummy smile and lower third (2024).
Training course on ‘Neuromodulators in aesthetic medicine’, Barcelona Medical Association (2024).
Lifting and Redensification facial treatment training, Galderma (2024).
“Galderma on stage” workshop: anatomy, Skinboosters treatments, collagen biostimulators, dynamic wrinkles, middle third and under-eye circles, lips, rhinomodeling, chin and complications (2024).
Formation of Sculptra corporal, Galderma (2024).
Course “Brighten your patients’ skin”, Galderma (2024).
Session “Discover the best profile of your patients”, Galderma (2024).
Galderma clinical session: Restylane Vital+Sculptra (2024).
Galderma training workshop: Harmony and balance of proportions (2024).
Teoxane Training Workshop: Facial Masculinization (2024).
IBSA training workshop: approach to transgender patients (2024).
Sinclair training workshop: Lanluma day (2024).
Sinclair Hands On: Body Lanluma (2024).
Training by the Barcelona Medical Association: Lasers and light sources in medicine (2024).
Training Spanish Society of Aesthetic Medicine: Anesthesia and Resuscitation in Aesthetic Medicine (2024).
Expert Diploma in Leadership in Aesthetic Medicine – CEU University (2023).
Webinar Skinbooster treatments and skin quality, Galderma (2023).
Allergan Hands On Training: Workshop on Facial Ultrasound as a diagnostic tool in the daily practice of Aesthetic Medicine (2023).
Allergan Training – Master Class: HarmonyCa and Juvederm (2023).
Allergan Behind Beauty 360º Training (2023).
Teoxane training: Lip training workshop (lip techniques, 2023).
Teoxane training: Clinical session (diagnosis of clinical cases, 2023).
Teoxane Academy Regional Congress – MLT 3.1 Technique (2023).
Fillmed training (Protocols: Bionutrishape, Bionutrilift, Bionutrilips, Full-face, 2023).
Fillmed training (Dermatocosmetica, 2023).
Sinclair Hands On (Ellansé and Maili).
Neauvia formation: hyaluronic acid + pen plasma (2023).
Training Galderma Botulinum toxin liquid: Alluzience (2023).
Galderma Formation: Sculptra + Lyft (2023).
Galderma training: dissection of cadavers (ACME Mallorca, 2023).
IBSA Hands On Training (Profhilo, Skinko, 2023).
IBSA Training: Approach to complicated lips (2023).
IFMIL Training- Basic Life Support Course + DEA (Consell Català de Ressuscitació, 2023).
IFMIL Training-Theoretical and practical workshop on minor outpatient surgery (cutaneous, subcutaneous, continuous and discontinuous sutures, wound management and dermatological lesions, 2023).
Training by the Barcelona Medical Association: Adverse effects with materials (2023).
Thermage Hands On Training (2023).
Candela laser training: Nordlys IPL (PR 530 and VL 550) (2023).
Lumenis laser training: IPL and ERBIO YAG (2023).
Lumenis Laser Formation: CO2 (AcuPulse, 2023).
HANDY Laser Training – Plasma Pen (2023).
Master Class: Rejuvenation of face / neck / neckline / hands – by CO2 laser (2023).
Master Class: Non-surgical eyelid retraction & Endolifting (2023).
Aesthetic Surgery Training: Endolifting (2023).
Aesthetic Surgery Training: Nanofat (2023).
Facial and Body Aesthetic Surgery Training: Lipolaser with Liposuction (2023).
Allergan Hands on training: Hyaluronic acid middle/lower/upper third (MD Codes- Mauricio di Maio, 2022).
Allergan Hands on Training: HarmonyCa (2022).
Allergan Hands on Training: Botulinum Toxin (2022).
Teoxane formation: Hyaluronic acid (middle/lower/upper third, 2022).
Teoxane training in collaboration with Cardenal Herrera University: Expert in leadership in Aesthetic Medicine – Training in marketing, sales, facial treatments (2022).
Galderma formation: hyaluronic acid (middle/lower/upper third, 2022).
Galderma training: Sculptra collagen stimulator, Skinbooster (2022).
Merz Formation: Radiesse (2022).
Chroma Formation: Hands on Juvenus Medium-Strong/Skinbooster Rich pure (2022).
Dermica Laboratoires Training: Penis thickening with hyaluronic acid (2022).
Medyglobal Tornado/ Harpoon/ Screwcog (2022).
Medyglobal Training: Body hyaluronic acid and Buttock Treatment DeneB H. (2022).
Medyglobal/Merz Training: Buttock Reshaping with Radiesse and PDO Threads (2022).
Sinclair Training: Buttock Augmentation and Reshaping with Lanluma (2022).
Regenlab (Blisscare) training: PRP/Cellular Matrix (2022).
Regenlab (Blisscare) training: PRP/Cellular Matrix (2022).
Training Spanish Society of Aesthetic Medicine: Filler implants in aesthetic medicine with classroom practice (2022).
Training Spanish Society of Aesthetic Medicine: Collagen Stimulators (2022).
Training Spanish Society of Aesthetic Medicine: Facial flaccidity (2022).
Training Spanish Society of Aesthetic Medicine: Dermatoscopy, teledermatology and topographic dermatology in Primary Care (2022).
Training Spanish Society of Aesthetic Medicine: Business Management in Aesthetic Medicine (2022).
Training Spanish Society of Aesthetic Medicine: Business Management in Aesthetic Medicine (2022).
Training Official College of Physicians of Barcelona: New developments in facial treatments—gummy smile/lower third/dark circles (2022).
Training Official College of Physicians of Barcelona: New developments in the prevention and diagnosis of chronic venous disease (2022).
Training Catalan Society of Aesthetic Doctors: Facial fillers: Lights and shadows (2022).
Fellowship at Clinica Now in Portugal with Dr. Abraham Valência (2022).
Pronokar Formation (2022).
Lipedema training (2022).
National Congress of SEME and SERECAP, Malaga (2022).
Accreditation for the use of Botulinum Toxin in Aesthetic Medicine (2021).
Allergan Botulinum Toxin Training (2021).
PRP Hy-Tissue/ QREM CYTOKINE Training (2021).
Specialization Diploma in Musculoskeletal Ultrasound – UFV Madrid (2021).
Specialization Master in Aesthetic Medicine – University of Cordoba, Spain (2020-2021).
Workshop on facial fillers with hyaluronic acid, results of radiofrequency and microneedling techniques (2020).
Refresher course on the injection of fillers in the body (2019).
Course Basic Life Support +DEA – Consell Català de Ressuscitació (2019).
Master Course Facial Rejuvenation (2018).
Bachelor of Medicine and Surgery, Carol Davila University, Bucharest (2011-2017).
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