Polynucleotides for smoother, brighter-looking skin with less noticeable fine lines.
Brighter, more even-looking skin, improved elasticity and less noticeable fine lines: Rejuran can help you achieve these improvements gradually.
Its polynucleotides support hydration and the skin’s natural repair processes, helping to improve texture and appearance both on the face and around the eyes.
During your consultation, we assess what each area needs, what changes you can expect and how to incorporate the treatment into your skincare plan.
We provide guidance based on medical expertise.
Rejuran is a brand of injectable polynucleotides. These are purified DNA fragments derived from salmon, injected into the dermis to support hydration and the skin’s natural repair processes. They help improve overall skin quality, with smoother texture, better hydration, a brighter complexion and less noticeable fine lines.
At Clínica Provença, we use Rejuran for the face and under-eye area, including certain types of dark circles. The choice of product depends on the area and what we want to improve.
Rejuran may be suitable when your main concerns relate to skin texture and quality. Your skin may feel thinner, look dull or dehydrated, show fine lines or appear less even than before.
It can be a good option when skin starts to lose thickness and radiance, or as part of a wider skincare plan alongside other treatments. We use Rejuran for the face and Rejuran i for the delicate skin around the eyes.
In the under-eye area, it is important to understand the cause before treating. What you see beneath your eyes may be related to skin texture (thin skin, reduced density or fine lines), its colour, or the underlying anatomy (a shadow caused by volume loss or an under-eye bag). Often, several factors overlap. Rejuran i works on the skin itself: it can improve texture and density, and may also reduce the appearance of darkness. How much improvement is possible depends on the cause of your under-eye concerns. When several factors are involved, it forms part of the treatment plan rather than the entire solution. We explain this in more detail in our guide to what causes dark circles under the eyes.
When your concern comes from deeper structures (loss of support, a hollow, sagging or an under-eye bag), Rejuran is not the right treatment. The focus then needs to be on the structures supporting the skin, using techniques that restore support or address facial sagging. During your consultation, we assess which approach is appropriate for you.
Aesthetic doctor, educator in aesthetic medicine and director of Clínica Provença.
Treatments guided by medical judgment, with personalised planning and a conservative approach.
Licensed physician No. 55671 · Barcelona Medical Association
Our aim is brighter, more even-looking skin that feels softer and more hydrated, with better elasticity and less noticeable fine lines. As texture improves, pores may also look less visible in some skin types. Around the eyes, treatment can help soften small wrinkles and improve skin appearance. Depending on the cause of your dark circles, the darkness may also become less noticeable, giving the eye area a more rested appearance.
Initial changes may become noticeable after two to four weeks. Improvement is gradual and is best assessed over the weeks following the initial treatment course. Before starting, we agree on your goals and monitor your progress to decide how to proceed.
To maintain results, we generally recommend a maintenance session after six to nine months, depending on how your skin responds and how long the improvements last. Sun protection and consistent daily skincare complement treatment and support long-term skin health.
Before treatment, we apply a topical anaesthetic cream to reduce discomfort. The doctor then makes a series of small, very superficial injections in the agreed area. The injections take around 20 to 30 minutes, plus the time needed for the anaesthetic to take effect.
Small raised bumps are common at the injection sites immediately after treatment. They are caused by the product before it has fully settled into the skin and usually subside within one or two days. Mild redness or small bruises may also occur. If you have an important event coming up, we will schedule your appointment with enough time beforehand.
For the first 24 hours, avoid makeup, strenuous exercise, intense heat such as saunas and massaging the treated area. Before you leave, we explain the aftercare guidance and when you can return to your usual routine.
We listen to your concerns and what you hope to achieve.
We assess your skin (thickness, texture, hydration and fine lines) and whether what you see originates in the skin itself or the structures supporting it, which may require a different approach. If dark circles concern you, we also look at what is causing them: the skin, its colour or the anatomy underneath.
We give you a considered medical recommendation: what is appropriate for your case, what isn’t and why. Sometimes another technique makes more sense; sometimes no treatment is needed.
You leave with a treatment plan and a cost estimate, and can take your time to decide.
Would you like us to assess your case?
We’ll go through the available options with you.
Free initial consultation · 30 minutes
At first, this is to be expected. Rejuran does not work instantly: it stimulates your skin’s cells to repair themselves and produce collagen, a process that takes several weeks. Each session builds on the previous one, so changes after the first treatment may be subtle and become more noticeable as the course progresses.
Rather than relying on impressions alone, we agree on your treatment goals before starting. At each session, the doctor assesses how your skin is responding and adjusts the plan if needed.
Before treatment, we apply a topical anaesthetic cream to reduce discomfort. The injections are very superficial and feel like small pinpricks; their intensity varies depending on the area and your sensitivity. Most people tolerate the procedure well.
A typical course consists of three sessions, about one month apart, followed by maintenance depending on how well your skin retains the improvements.
Rejuran is a brand name, while polynucleotides are the type of product. Several brands exist, with different formulations. Here, we explain how we use Rejuran specifically.
Not exactly. Healer and HB are names used for injectable products in the Rejuran range sold in other markets, particularly in Asia. HB (also known as HB Plus) has a different formulation: it combines polynucleotides with hyaluronic acid and lidocaine. A different range is marketed in Europe, and we use two products from it: Rejuran and Rejuran i.
Rejuran creams and serums are cosmetic products containing a different ingredient from the injectable formulation. Some are also called Healer, which adds to the confusion. They can be part of your daily skincare routine, but they do not have the same action as the injectable treatment. If you’ve had Rejuran treatment in another country, bring the product name or a photo so we can identify it.
Both improve skin quality, but they address different concerns. Profhilo is a highly concentrated hyaluronic acid treatment that spreads through the skin, hydrates it deeply and improves firmness. It may suit skin that feels less supple or is showing mild laxity around the cheeks or neck.
Rejuran is a polynucleotide treatment that supports the skin’s repair processes and focuses on texture, visible pores and fine lines. It may be suitable when skin feels thinner, rougher or duller, and there is a formulation designed for the delicate eye area. If both sets of concerns apply, the treatments can sometimes be combined in a sequence tailored to you.
We do not administer Rejuran during pregnancy or breastfeeding, or in areas with an active infection or inflammation. If you have a fish allergy, an autoimmune condition or take anticoagulant medication, please tell us during your consultation. In some cases, treatment may not be advisable; we review this in the context of your medical history. Do not stop taking any medication without medical advice.
Rejuran has a known and well-documented safety profile. Before treatment, we discuss the potential risks and aftercare with you.
Clínica Provença is located in Barcelona, Spain, at Carrer de Roger de Llúria 89, 08009 Barcelona, in a central and well-connected area.
You will find us just a few minutes from the Diagonal (L3 and L5) and Girona (L4) metro stations, as well as Passeig de Gràcia train station (Rodalies) and FGC Provença.
Reviewed by Dr. Manuela Gheorghiu
Last reviewed: November 2026
Dr. Manuela Gheorghiu is the Medical Director of Clínica Provença in Barcelona, where she defines the clinic’s clinical standards and treatment protocols, and practices as an aesthetic doctor.
Professor of the Master in Aesthetic Medicine and Comprehensive Rejuvenation of the Catholic University of Valencia and the European Medical College.
Graduated in Medicine and Surgery with highest honours from the Carol Davila University of Medicine and Pharmacy in Bucharest, with her medical degree officially recognised in Spain.
She completed her specialised training in Aesthetic Medicine in Spain, earning a Master’s Degree in Aesthetic Medicine from the University of Córdoba.
She maintains ongoing scientific training, with a strong focus on clinical safety and precision in both treatment indication and execution.
Member of the College of Physicians of Barcelona (COMB), with the number of collegiate 55671, and holder of the Diploma of Accreditation of Training in Aesthetic and Cosmetic Medicine (DIACAP), issued by the COMB.
Member of the Spanish Society of Aesthetic Medicine (SEME) with the number 2729.
Member of the Association of Aesthetic Doctors of Catalonia (SMEC) with the number 65.
Member of the Spanish Society of Fat Transplant Applications (SETGRA).
Professor of the Master in Aesthetic Medicine and Comprehensive Rejuvenation of the Catholic University of Valencia and the European Medical College.
Advanced training and ongoing participation in specialised national and international programmes in Aesthetic Medicine.
Her main areas of expertise include:
Inject Art Lab Course, Advanced Clinical Training in Regenerative Aesthetic Medicine, IT Pharma (2026).
Full-Face and Anatomy workshop, Croma Anatomy, Medical University of Vienna, Center for Anatomy and Cell Biology (2026).
Ultrasound in Aesthetic Medicine: Present and Future, Barcelona Medical Association (2026).
41st National Congress of Aesthetic Medicine and 7th SERECAP Congress (Spanish Society of Hair Restoration), 2026.
Practical fundamentals of aesthetic ultrasound, Dermica Laboratories (2026).
Dermamelan Expert Meeting: leading medical approach to depigmentation, Mesoestetic (2025)
Latest trends in Thread Tightening: Anatomy, advanced technique and results, Croma (2025).
Buttock approach: “New Round Raised Technique”, Dermica Laboratoires (2025).
Galderma Gain Spark Training: “Shaping Progress in Aesthetics’ Real-World Knowledge, Highlighting the latest trends and treatment innovation” (2025).
Well Aging training module: mastering the art of “less is more” and stimulating collagen production for better skin quality, Galderma (2025).
Hands on Sculptra, collagen biostimulator, Galderma (2025).
Seminar on ‘Addressing Facial Sagging in Aesthetic Medicine,’ Barcelona Medical Association (2025).
“Natural Beauty” training: enhance natural beauty with facial harmonization techniques and dynamic wrinkle treatment, Galderma Academy (2025).
Professional seminar ‘Medical-aesthetic treatment with hyaluronic acid in the mid-face and under-eye area’, Barcelona Medical Association (2025).
24th World Congress of Aesthetic Medicine (2025).
40th Congress of the Spanish Society of Aesthetic Medicine (2025).
Nuceiva neuromodulator training, anatomy and clinical results, Evolus Inc. (2024).
Hands on: Launch of Galderma’s NEW neuromodulator Relfydess (2024).
Practical Theoretical Workshop – Special: Collagen Biostimulator, Galderma (2024).
Skymedic Regenerative Day: Exosomes, advanced photobiodynamic therapy and carboxytherapy (2024).
Teoxane’s course in Aesthetic Medicine, advanced level: facial anatomy, middle third and redensification, upper third, rheology, eyebrows, lips and gummy smile and lower third (2024).
Training course on ‘Neuromodulators in aesthetic medicine’, Barcelona Medical Association (2024).
Lifting and Redensification facial treatment training, Galderma (2024).
“Galderma on stage” workshop: anatomy, Skinboosters treatments, collagen biostimulators, dynamic wrinkles, middle third and under-eye circles, lips, rhinomodeling, chin and complications (2024).
Formation of Sculptra corporal, Galderma (2024).
Course “Brighten your patients’ skin”, Galderma (2024).
Session “Discover the best profile of your patients”, Galderma (2024).
Galderma clinical session: Restylane Vital+Sculptra (2024).
Galderma training workshop: Harmony and balance of proportions (2024).
Teoxane Training Workshop: Facial Masculinization (2024).
IBSA training workshop: approach to transgender patients (2024).
Sinclair training workshop: Lanluma day (2024).
Sinclair Hands On: Body Lanluma (2024).
Training by the Barcelona Medical Association: Lasers and light sources in medicine (2024).
Training Spanish Society of Aesthetic Medicine: Anesthesia and Resuscitation in Aesthetic Medicine (2024).
Expert Diploma in Leadership in Aesthetic Medicine – CEU University (2023).
Webinar Skinbooster treatments and skin quality, Galderma (2023).
Allergan Hands On Training: Workshop on Facial Ultrasound as a diagnostic tool in the daily practice of Aesthetic Medicine (2023).
Allergan Training – Master Class: HarmonyCa and Juvederm (2023).
Allergan Behind Beauty 360º Training (2023).
Teoxane training: Lip training workshop (lip techniques, 2023).
Teoxane training: Clinical session (diagnosis of clinical cases, 2023).
Teoxane Academy Regional Congress – MLT 3.1 Technique (2023).
Fillmed training (Protocols: Bionutrishape, Bionutrilift, Bionutrilips, Full-face, 2023).
Fillmed training (Dermatocosmetica, 2023).
Sinclair Hands On (Ellansé and Maili).
Neauvia formation: hyaluronic acid + pen plasma (2023).
Training Galderma Botulinum toxin liquid: Alluzience (2023).
Galderma Formation: Sculptra + Lyft (2023).
Galderma training: dissection of cadavers (ACME Mallorca, 2023).
IBSA Hands On Training (Profhilo, Skinko, 2023).
IBSA Training: Approach to complicated lips (2023).
IFMIL Training- Basic Life Support Course + DEA (Consell Català de Ressuscitació, 2023).
IFMIL Training-Theoretical and practical workshop on minor outpatient surgery (cutaneous, subcutaneous, continuous and discontinuous sutures, wound management and dermatological lesions, 2023).
Training by the Barcelona Medical Association: Adverse effects with materials (2023).
Thermage Hands On Training (2023).
Candela laser training: Nordlys IPL (PR 530 and VL 550) (2023).
Lumenis laser training: IPL and ERBIO YAG (2023).
Lumenis Laser Formation: CO2 (AcuPulse, 2023).
HANDY Laser Training – Plasma Pen (2023).
Master Class: Rejuvenation of face / neck / neckline / hands – by CO2 laser (2023).
Master Class: Non-surgical eyelid retraction & Endolifting (2023).
Aesthetic Surgery Training: Endolifting (2023).
Aesthetic Surgery Training: Nanofat (2023).
Facial and Body Aesthetic Surgery Training: Lipolaser with Liposuction (2023).
Allergan Hands on training: Hyaluronic acid middle/lower/upper third (MD Codes- Mauricio di Maio, 2022).
Allergan Hands on Training: HarmonyCa (2022).
Allergan Hands on Training: Botulinum Toxin (2022).
Teoxane formation: Hyaluronic acid (middle/lower/upper third, 2022).
Teoxane training in collaboration with Cardenal Herrera University: Expert in leadership in Aesthetic Medicine – Training in marketing, sales, facial treatments (2022).
Galderma formation: hyaluronic acid (middle/lower/upper third, 2022).
Galderma training: Sculptra collagen stimulator, Skinbooster (2022).
Merz Formation: Radiesse (2022).
Chroma Formation: Hands on Juvenus Medium-Strong/Skinbooster Rich pure (2022).
Dermica Laboratoires Training: Penis thickening with hyaluronic acid (2022).
Medyglobal Tornado/ Harpoon/ Screwcog (2022).
Medyglobal Training: Body hyaluronic acid and Buttock Treatment DeneB H. (2022).
Medyglobal/Merz Training: Buttock Reshaping with Radiesse and PDO Threads (2022).
Sinclair Training: Buttock Augmentation and Reshaping with Lanluma (2022).
Regenlab (Blisscare) training: PRP/Cellular Matrix (2022).
Regenlab (Blisscare) training: PRP/Cellular Matrix (2022).
Training Spanish Society of Aesthetic Medicine: Filler implants in aesthetic medicine with classroom practice (2022).
Training Spanish Society of Aesthetic Medicine: Collagen Stimulators (2022).
Training Spanish Society of Aesthetic Medicine: Facial flaccidity (2022).
Training Spanish Society of Aesthetic Medicine: Dermatoscopy, teledermatology and topographic dermatology in Primary Care (2022).
Training Spanish Society of Aesthetic Medicine: Business Management in Aesthetic Medicine (2022).
Training Spanish Society of Aesthetic Medicine: Business Management in Aesthetic Medicine (2022).
Training Official College of Physicians of Barcelona: New developments in facial treatments—gummy smile/lower third/dark circles (2022).
Training Official College of Physicians of Barcelona: New developments in the prevention and diagnosis of chronic venous disease (2022).
Training Catalan Society of Aesthetic Doctors: Facial fillers: Lights and shadows (2022).
Fellowship at Clinica Now in Portugal with Dr. Abraham Valência (2022).
Pronokar Formation (2022).
Lipedema training (2022).
National Congress of SEME and SERECAP, Malaga (2022).
Accreditation for the use of Botulinum Toxin in Aesthetic Medicine (2021).
Allergan Botulinum Toxin Training (2021).
PRP Hy-Tissue/ QREM CYTOKINE Training (2021).
Specialization Diploma in Musculoskeletal Ultrasound – UFV Madrid (2021).
Specialization Master in Aesthetic Medicine – University of Cordoba, Spain (2020-2021).
Workshop on facial fillers with hyaluronic acid, results of radiofrequency and microneedling techniques (2020).
Refresher course on the injection of fillers in the body (2019).
Course Basic Life Support +DEA – Consell Català de Ressuscitació (2019).
Master Course Facial Rejuvenation (2018).
Bachelor of Medicine and Surgery, Carol Davila University, Bucharest (2011-2017).
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